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In the 1990s, scientist Ivan Casas traveled to the Peruvian Andes in search of human microbes. Casas was head of research for a Swedish probiotics company called BioGaia. He believed that mammals, including people, passed beneficial microbes to their young via breast milk. But he’d been unable to isolate one species he thought should be there (Lactobacillus reuteri) in breast milk from women in the US or urban areas

For the microbiologist Justin Sonnenburg, that career-defining moment—the discovery that changed the trajectory of his research, inspiring him to study how diet and native microbes shape our risk for disease—came from a village in the African hinterlands. A group of Italian microbiologists had compared the intestinal microbes of young villagers in Burkina Faso with those of children in Florence, Italy. The villagers,

Eugene Rosenberg, a coral microbiologist, ran into a rather large problem in the early 2000s. While working at the University of Tel Aviv in Israel, he discovered that he couldn’t replicate his own breakthrough findings from a decade earlier. What seemed like a potentially devastating failure at the time would lead Rosenberg to a new way of thinking about evolution. In the 1990s, he’d discovered a driver of coral dis