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In recent decades, the prevalence of asthma and allergies has increased between two- and threefold in the United States. These days, one in 12 kids has asthma. More are allergic. The uptick is often said to have started in the late 20th century. But the first hint of a population-wide affliction — the sneezing masses — came earlier, in the late 19th century, among the American and British upper classes. Hay fever so

When Vik was in his late 20s, blood started appearing in his stool. He found himself rushing to the bathroom as many as nine times a day, and he quit his job at a software company. He received a diagnosis of severe ulcerative colitis, an inflammatory condition of the colon. Steroids, which suppress inflammation, didn’t work for him. Sulfasalazine suppositories offered only the slightest relief. A year and a half afte

I have a piece in the NYT Mag on the community of people who self-treat with parasites. They operate almost entirely outside of any regulatory or medical oversight. This is a story about desperate people trying to cure themselves with an unproven therapy. It’s not a story about whether the therapy works. We don’t know if it does. And in fact, there’s good evidence, in the form of double-blinded placebo-controlled stu

IN the last half-century, the prevalence of autoimmune disease — disorders in which the immune system attacks healthy tissue in the body — has increased sharply in the developed world. An estimated one in 13 Americans has one of these often debilitating, generally lifelong conditions. Many, like Type 1 diabetes and celiac disease, are linked with specific gene variants of the immune system, suggesting a strong geneti

In the 1990s, scientist Ivan Casas traveled to the Peruvian Andes in search of human microbes. Casas was head of research for a Swedish probiotics company called BioGaia. He believed that mammals, including people, passed beneficial microbes to their young via breast milk. But he’d been unable to isolate one species he thought should be there (Lactobacillus reuteri) in breast milk from women in the US or urban areas

Some of the disparity in the risk from BRCA mutations is generational. One repeated finding is that, by age 50, mutation carriers born in the early twentieth century seem to have a lower risk of cancer than those born later3. The pattern suggests that outside influences interact with genes, and that something in the environment has changed in an unfavourable way. If researchers can figure out what those influences ar

For the microbiologist Justin Sonnenburg, that career-defining moment—the discovery that changed the trajectory of his research, inspiring him to study how diet and native microbes shape our risk for disease—came from a village in the African hinterlands. A group of Italian microbiologists had compared the intestinal microbes of young villagers in Burkina Faso with those of children in Florence, Italy. The villagers,

Here’s an hour-long conversation with Russ Roberts over at EconTalk. Very gracious host. I love it that after reading Epidemic, people say, “I bet I had worms.”